The KHIT Blog: How the “culture of science” plays into the “reproducibility crisis”

Tuesday, October 29, 2019

How the “culture of science” plays into the “reproducibility crisis”

A call for interested, knowledgeable interviewees.

We’re making an NIH-funded podcast on a very important topic! Maybe we want to interview you!
Tiffany Doherty

We are creating a podcast about science culture! Specifically, it is a podcast that will be accompanied by educational modules (all NIH funded) addressing how the “culture of science” plays into the “reproducibility crisis”.

We are focusing on the “why” behind the “how”. Meaning rather than focusing on p-hacking/image duplication/fabricated data, we’re focusing on what drives people to p-hack/duplicate images/fabricate data. We want to examine, among other things, the incentive systems put into place by universities, granting agencies, & publishers, and how that contributes to poor research.

A (non-exhaustive) list of things we plan to cover:

How quantity over quality is rewarded in hiring, tenure/promotion, funding, publishing

Media coverage (fame factor and how the media doesn’t report on null results)

Conflicts of interest (professional, ideological, financial)

Poor oversight/mentoring (including how that can trickle down scientific “generations”)

Authority structure

Particularly in terms of those last two: We want to talk to people who have felt pressure from mentors (likely during grad school or postdoc) to conduct inappropriate analyses and/or other data/publication related tasks for the sake of publishing specific and/or significant results. We want to hear from you whether you felt comfortable doing what was asked of you or not, whether you complied or did not. There is no judgement, only the wish to talk about an issue that is difficult to quantify precisely because we do not talk about it. We can take measures to anonymize you if you prefer.

If you have stuff to say about any of the above, we want to hear from you!!! You can e-mail Tiffany at tsdohert@iu.edu or DM her on Twitter @DrTiff_

We’ll likely conduct a pre-interview over the phone (less than 20 minutes) to make sure we’ll have plenty of relevant and interesting things to discuss, and if we all feel like it’s a go, we’ll get you scheduled for an interview. We’ll come to you and work around your schedule. The interview itself would be around an hour, and it’s not live, so we can edit anything. Very low pressure. We want this to be as easy on you as possible.

In addition, if you have further topics related to this angle that you think we should consider, we want to hear about it! And if you know someone who would be awesome but not likely to see this, we want to hear about them, too!

Originally posted at The Incidental Economist. Important topic.

I spoke with Dr. Doherty today to encourage this initiative. All that good science stuff. Been riffing on it a lot of late. "Define 'science,'" "Why trust science?"

They need to interview Dr. Oreskes, big-time.

NEW ON THE BOBBYG BOOKSHELF

So much to continue to learn. Just finished "Winners Take All." Excellent.
_____________

More to come...

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Brave New Health

Commonwell Health Alliance

Another important read (pdf)

I love this kind of stuff. It sustains and humbles me. "As politicians, advertisers, salesmen, and propagandists for various political, economic, moral, religious, psychic, environmental, dietary, and artistic doctrinaire positions know only too well, fallible human minds are easily tricked, by clever verbiage... Common language—or at least, the English language—has an almost universal tendency to disguise epistemological statements by putting them into a grammatical form which suggests to the unwary an ontological statement. A major source of error in current probability theory arises from an unthinking failure to perceive this."

Quotes

"An economist is a person who sees something that works in practice and tries to figure out whether it will work in theory."

- J.D. Kleinke, medical economist
___

"The only person who enjoys change is a baby with a wet diaper."

"Every misspent dollar in our health care system is part of somebody's paycheck.

- Brent James, M.D., M.Stat

“We could do healthcare, at markedly higher quality, for everyone in this country, without rationing or denying anybody the care that they need, without having the government dictate how doctors practice or whether hospitals could expand, at half the cost we do it now.”

- Health Care Futurist Joe Flower

Most of the sciences, unlike parts of medical science, are not concerned with the impossible. There is not complementary and alternative physics, or chemistry, or biochemistry, or engineering. These disciplines compare their ideas against reality, and, if the ideas are found wanting, abandoned."

- Mark A. Crislip, MD

"Q: How much alcohol is too much?
A: More than your doctor drinks."

- a physician I once heard speak during a CME presentation

“Just because science doesn’t know everything, doesn’t mean you get to fill in the gaps with whatever fairy tale most appeals to you.”

- Dara O’Briain

'[I]t is one small step from using the computer for "helping" doctors to monitoring them, judging them, dictating to them what to do, and withdrawing payment for computer non-compliance. The use of computer data is a multi-edged sword. It can be used for the "good," facilitating diagnosis and treatment and making it more accurate and up-to-date, and for “evil,” invading privacy, inviting security breechs, and making decisions based on the opinions of remote authorities rather than those present at the patient-doctor encounter.'

- Richard Reece, MD

“[T]here ARE statistics which are non-political. Just because The Washington Post/Fox News reports the temperature is 75 degrees doesn’t mean it’s really snowing and sunscreen is a liberal/conservative plot. Even if you earn a living being ideological.”

- Michael L. Millenson

"It is a generally a fairly convincing argument that people shouldn’t have to be subsidized to undertake a change which is in their best interest.

The reconciliation seems to be that EHR is not supposed to make a doctor’s practice more efficient and higher quality. It is supposed to make the system of care more efficient and higher quality, which is not the same thing. Those of you who took calc recall that maximizing the total of variables is not achieved by maximizing any one variable and this is a perfect example of that.

Those of you have served in combat certainly noticed that too — if everyone works as a team the unit takes fewer casualties. If you try to save your own hide, you might, but at the expense of more casualties overall."

- Al Lewis

"There are two ideas to keep in mind about Bayesian reasoning and how we tend to mess it up. The first is that base rates matter, even in the presence of evidence about the case at hand. This is often not intuitively obvious. The second is that intuitive impressions of the diagnosticity of evidence are often exaggerated."

- Daniel Kahneman, "Thinking, Fast and Slow"

"Physicians apply advanced scientific knowledge, but they must do so without the favorable conditions that experimental scientists create for themselves. Multitasking is forced on physicians, often in chaotic environments and under severe time and resource constraints."

- Lawrence and Lincoln Weed, "Medicine in Denial"

"It’s time to stop the whining about Obama care and acknowledge we already have universal health care. We just pay for it in the stupidest way possible that ensures problems are that much more disastrous and complicated when they’re finally treated."

- Mark Hoofnagle, MD, PhD

"Every act of conscious learning requires the willingness to suffer an injury to one's self-esteem. That is why young children, before they are aware of their own self-importance, learn so easily."

- Thomas Szasz, MD
___

"Of course, one reason that process metrics* are so popular is that processes are much easier to define and measure than outcomes."

- The Skeptical Scalpel
___

"There is an “illusion of validity” for any random data point, a seductive sense that is colored by what we hope will be true. Mountains of pharmaceutical claims are often made from mere molehills of data."

- Danielle Ofri, MD
___

"Joy empowers people. It is a source of energy that enables people to hope and plan and change their lives for the better. Spend some time around someone who is relentlessly negative and how do you feel–drained, right? More and more research shows that joy is not something that just happens to you, like a bolt of lightening out of the blue. Joy is, instead, a habit to cultivate. Negative thinking and despair are the crabgrass of our souls–weeds that take root and spread, sometimes to all areas of life. Joy, in contrast, is a soul’s rose–hardy when cared for, able to put down roots over time and withstand disease and extremes. Like a rose, however, your joy can become blighted from neglect or harsh conditions. We all need to tend to our joy–to prune away the badness, and to know that, even though it may look like a prickly bare root, if you invest time in a joyous outlook, gorgeous things will bloom, even in the harshest conditions."

- Dr. Jan Gurley
___

"'Solutions' exist only in mathematics."

- Karen Martin
___

"The issue of how to regulate clinical software is, in the long run, indistinguishable from the issue of how to regulate medicine. The only difference is that medicine is practiced in the open, without secrecy, subject to peer review, and under a merit-based state license."

- Adrian Gropper, MD
___

"Economist, rope, tree: some assembly required."

- Source unknown

DISCLAIMER:

I write this blog wholly on my own time and my own dime. The views proffered are expressly my own as a concerned and active citizen/taxpayer (in addition to being the result of my substantive experience in the various IT fields), and in no way reflect any policy views of my former employer, notwithstanding that some of the thinking has indeed obviously been spurred by the implications of the work with which I have been doing for them.

FAIR USE POLICY
I cite a ton of news and web sources spanning the breadth of relevant technical and policy domains, sometimes at substantial length. I believe I remain well within the bounds of "Fair Use," as [1] I am not doing any of this for profit, [2] I always provide attribution and links -- which, [3] far from negatively impacting any copyright holders' commercial interests, might actually increase traffic to and interest in their offerings.

Nonetheless, should I post anything of yours regarding which you have any objection, just let me know and I will remove it forthwith.

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Tuesday, October 29, 2019

How the “culture of science” plays into the “reproducibility crisis”

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