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Wednesday, January 20, 2021

"Cleanup on Aisle 45"

ME We the People.
 12:01 pm, January 20th, 2021.
The End of an Error.

At the conclusion of his one-term-twice-impeached tenure, in the wake of a seemingly endless onslaught of belligerent threats and denial — capped by a brazen, overt incitement of a ghastly lethal insurrection on January 6th at the Capitol— Tough Guy Trump feebly collapsed like a worn-out, cheap picnic folding chair. Good riddance.

Saturday, January 16, 2021

This American Carnage

I've been transcribing daily US Covid-19 "incidence" data (daily confirmed new cases) from the Hopkins site since Q4-2020. Yesterday I added an Excel tab for daily US deaths commencing January 1st, 2021. More than 46,000 fatalities across the first 15 days of the month. Total US Covid mortality since the pandemic ensued is today about 390,000.
3.5 million new US cases across January through the 15th. We're going to easily lose more than a half million people. 

Recapping, the US comprises 4.3% of world population, and about 25% of the Covid cases and 20% of deaths.


Monday, January 11, 2021

Is THIS what we've come to?

Are we heading toward widespread violent anarchy?
Click the image.
Not what I want to be posting about. But, we now have the most exigent of circumstances. If we fail to abate and reverse this growing sociopolitical psychosis, not much else will matter.

Buckle up, America.

apropos, see my Feb 2020 post "For Sama." Anyone who thinks civil war would be fun is crazy.

Meanwhile the Covid19 pandemic continues to surge.
2.4 million new US cases across the first 10 days of January. 3-4,000 US deaths per day, hospitals running out of space. Total US Covid deaths now approaching 400k. Vaccine distribution and inoculations still way behind the curve.
Click the image.

Again, click the image.

A reflection on our debacle posted on Facebook the other day.
WHAT BROUGHT US TO THIS POINT? There were 5 principal conditions that led to the events of January 6th in the U.S. Capitol.

When the Democrats under Presidents Kennedy and Johnson allied with the civil rights movement, southern Democrats began leaving the party. Republican Richard Nixon then deliberately used race as a wedge issue to split the Democrats and appeal to white working people. The Republican Party has continued to exploit racial politics since then.

2. ECONOMIC CHANGE. The short period in the 1950s-60s in which the U.S. working class was doing well economically was an aberration in the history of capitalism. Shared economic prosperity in the U.S. was a result of World War II: economic spinoffs from massive government investment for the war and the war’s destruction of economic competition from Europe and Japan. These conditions changed by the 1970s as Europe and Japan began to recover and compete again. To maintain profits, the investing class instituted a program of neo-liberalism: reducing the power of unions; cutting taxes, regulations and social welfare programs; and advancing a global financial system. The economic conditions of working people in the U.S. began a decades-long decline. First the Republican Party under Reagan and then the Democratic Party under Clinton adopted the neo-liberal program.

Racial resentments and the economic decline of white working people fueled the growth of the white supremacy movement. It attracted military veterans from the wars in Vietnam, Afghanistan and Iraq. These veterans felt betrayed and abandoned by the government for sending them to wars that did not succeed; they also had military training and the capability for violence.
U.S. election laws support a two-party system in which voters have nowhere to go if the two dominant parties don’t seem to be responding to their needs. The economic frustrations of working people opened the opportunity for a political outsider to seek their votes. In the 1990s Ross Perot tapped this pool of voters in an unsuccessful independent run for the Presidency. Plurality elections in the Republican Presidential primary of 2016 (the candidate with the most votes, not necessarily a majority of the votes, wins) allowed Trump to attract enough of these voters to emerge as a front-runner when the other candidates split the majority of Republican votes between them. This opened the floodgates for more of these voters to support him.

5. EMERGENCE OF A DEMAGOGUE. President Trump has followed a classic fascist playbook of weakening democratic norms, encouraging extra-government militias, and using “big lies” to divide and confuse the public. These tactics all came together in his attempt to incite a mob of his supporters, likely led by white supremacist militias, to invade the U.S. Congress in an attempt to overturn the 2020 election.
Alan is a friend. I invariably call him my favorite graduate school professor (UNLV Institute for Ethics and Policy Studies, 1994-1998). A standout among a standout faculty. He and his family now live in Oregon. I asked his permission to re-post his remarks.

I am the offspring of a World War II Gold Star family. My late dad left a leg behind in Italy fighting nazis and fascists. He and all four of his brothers served for the duration. Only Pop and my uncle Warren survived the war years.

My late parents went on to be patriotic conservative Goldwater Republicans. I have subsequently been a ticket-splitting centrist independent, voting Republican as often as Democrat across my 74 years. When I retired and moved back to California in 2013, I registered as a Democrat, to be able to vote Democratic primaries.

Because I am now a “registered Democrat,“ I am told I am actually a “Communist.“

Because I am a middle-class white guy now living in Baltimore with a “Black Lives Matter” poster on my front door I am told that I should be killed.

Kiss my NY Irish ass.
Yes, this IS what we've come to.
I've been to our nation's capital many times. A couple of months ago most recently. Cheryl and I loaded up the dogs to do a quick get-outa-the-house day trip from Baltimore to DC, just to cruise around and maybe park and walk a bit.
I found it creepy this time. Concrete barriers everywhere, idling police cruisers with red and blue lights flashing, dump trucks blocking off streets... Mere portents.


January 15th, concertina wire Capitol.
Important, if dispiriting reading.

Thursday, January 7, 2021

"A Republic, if you can keep it"

A grotesque day in DC.

President Trump has now cemented his sordid legacy. And, at least four participants in his Jan 6th paroxysm of mass mindlessness have paid with their lives for acting on his incendiary exhortations.
We have promoted democracy in our movies and books. We speak of democracy in our speeches and lectures. We even sing about democracy, from sea to shining sea, in our national songs. We have entire government bureaus devoted to thinking about how we can help other countries become and remain democratic. We fund institutions that do the same.

And yet by far the most important weapon that the United States of America has ever wielded—in defense of democracy, in defense of political liberty, in defense of universal rights, in defense of the rule of law—was the power of example. In the end, it wasn’t our words, our songs, our diplomacy, or even our money or our military power that mattered. It was rather the things we had achieved: the two and a half centuries of peaceful transitions of power, the slow but massive expansion of the franchise, and the long, seemingly solid traditions of civilized debate…

Over the past four years, that example has been badly damaged. We elected a president who refused to recognize the democratic process. We stood by while some members of Donald Trump’s party cynically colluded with him, helping him break laws and rules designed to restrain him. We indulged his cheerleading “media”—professional liars who pretended to believe the president’s stories, including his invented claims of massive voter fraud. Then came the denouement: an awkward, cack-handed invasion of the Capitol by the president’s supporters, some dressed in strange costumes, others sporting Nazi symbols or waving Confederate flags. They achieved the president’s goal: They brought the official certification of the Electoral College vote to a halt. House and Senate members and Vice President Mike Pence were escorted out of the legislative chambers. Their staff members were told to shelter in place. A woman was shot to death…
Click the image, read all of it.

Click the image.

Monday, January 4, 2021

Our #Covid19 "Dark Winter" ensues

Continuing my Excel chart.

Above, Q4-2020 through Jan 3rd 2021. The increased episodic recent inter-day +/- incidence volatility is mainly a function of Nov-Dec holidays' time off for testing personnel.

US Covid19 deaths have now surpassed 350,000. We could easily see 500,000 or more before too long. Dark Winter, indeed.

I'm as frustrated as anyone. Still lying way low.
Stay safe and well. Get vaxxed as soon as it's available.

And, let's hope we still have a functioning Constitutional Democracy (a "Republic," yeah, I know) after January 6th. A dicey week, on multiple fronts.

Monday, December 28, 2020

2020, ugh. What will 2021 bring?

There are three moments in the yearlong catastrophe of the covid-19 pandemic when events might have turned out differently. The first occurred on January 3, 2020, when Robert Redfield, the director of the Centers for Disease Control and Prevention, spoke with George Fu Gao, the head of the Chinese Center for Disease Control and Prevention, which was modelled on the American institution. Redfield had just received a report about an unexplained respiratory virus emerging in the city of Wuhan.

The field of public health had long been haunted by the prospect of a widespread respiratory-illness outbreak like the 1918 influenza pandemic, so Redfield was concerned…
Lawrence Wright
The influenza pandemic that began in 1918 killed as many as 100 million people over two years. It was one of the deadliest disasters in history, and the one all subsequent pandemics are now compared with.

At the time, The Atlantic did not cover it. In the immediate aftermath, “it really disappeared from the public consciousness,” says Scott Knowles, a disaster historian at Drexel University. “It was swamped by World War I and then the Great Depression. All of that got crushed into one era.” An immense crisis can be lost amid the rush of history, and Knowles wonders if the fracturing of democratic norms or the economic woes that COVID-19 set off might not subsume the current pandemic. “I think we’re in this liminal moment of collectively deciding what we’re going to remember and what we’re going to forget,” says Martha Lincoln, a medical anthropologist at San Francisco State University.

The coronavirus pandemic ignited at the end of 2019 and blazed across 2020. Many countries repeatedly contained it. The United States did not. At least 19 million  Americans have been infected. At least 326,000 have died. The first two surges, in the spring and summer, plateaued but never significantly subsided. The third and worst is still ongoing…
Click the title image.

The Trümperdämmerung is finally here, and it is every bit the raging dumpster fire that we, the unlucky audience for this drama, have come to expect. Is there anyone left who is surprised that the President is careening through the last days of his Administration with a reckless disdain that simply has no precedent in American public life? Still, the hardest thing to accept is that 2020 is not merely the year that Donald Trump’s luck ran out but that with it the country’s did, too. Sadly and yet inevitably, this terrible, wretchedly toxic year of pandemic death and economic distress, of partisan hatred and national protest, is the culmination of all that Trump has wrought and all that he is.

Now that 2020 is finally almost over, I find that I don’t want to remember it at all. (Though you should read Lawrence Wright’s definitive account of this Plague Year in this week’s New Yorker.) Perhaps this is simply because Trump has remained so defiantly and obnoxiously unrepentant, continuing his antics all the way to the end. He does not want to let go, to cede the spotlight, to renounce his outsized claim on our collective consciousness. It is my protest, our protest, to want so desperately to do so.

As it is, we are still in 2020, and I can barely summon the concerns and controversies of a year ago, when the most pressing political question in Washington was whether Trump’s former national-security adviser John Bolton would have to testify in the impeachment trial of the President. (Spoiler alert: he didn’t, though he would eventually call Trump unfit for office in a book whose contents he did not share with the United States Senate and the American public when it mattered most.) Now that the election and all the other mayhem associated with it have happened, it’s hard to recall that 2020 began with me wondering whether Biden still had a chance in the upcoming Democratic primaries, and pondering why the promising Presidential campaign of Kamala Harris had flamed out so quickly, before a single vote was cast. This was back when Trumpian outrages seemed less threatening to the literal health of the nation…

Monday, December 21, 2020


Actual Trump fundraising email.
Need one elaborate?

Thursday, December 17, 2020

Here come the non-Rx OTC Covid-19 in-home assays

Good idea? I guess we'll see.

Aussie vendor. First home kit to get an FDA EUA permit. What about QA concerns? I am not yet privy to any data. Stay tuned to this Bat Channel.
Our test is what’s called a fluorescent immunoassay. So we use a quantum dot nanoparticle, which we developed in conjunction with our friends at Thermo Fisher to create an ultra-bright fluorescent reporter to detect proteins of coronavirus. So ours is an antigen test which uses next-generation immunoassay technology to get improved performance on the existing immunoassay products that are in the market.” —Dr. Sean Parsons, Ellume CEO, during a BBC interview.
Like to see some clarification and independent verification on that.

The Authorized Product
Your product is a non-prescription home use test intended for the qualitative detection of SARS-CoV-2 nucleocapsid antigens from mid-turbinate nasal swabs that are self-collected by an individual age 16 years or older, or are collected by an adult from an individual 2 years of age and older. This test is intended for use in individuals with or without symptoms or other epidemiological reasons to suspect a COVID-19 infection.

The SARS-CoV-2 nucleocapsid protein antigen is generally detectable in mid-turbinate nasal swab specimens during the acute phase of infection. Positive results indicate the presence of viral antigens, but the clinical correlation with past medical history and other diagnostic information is necessary to determine infection status. Positive results in an asymptomatic individual are presumptive and may need to be confirmed with a molecular assay. Positive results do not rule out a bacterial infection or co-infection with other viruses

Negative results are presumptive and confirmation with a molecular assay, if necessary, for patient management may be performed. Negative results do not rule out SARS-CoV-2 infection and should not be used as the sole basis for treatment or management decisions for the individual, including infection control decisions. Negative results should be considered in the context of an individual’s recent exposures, history and the presence of clinical signs and symptoms consistent with COVID-19.

Test results from your product will be automatically reported to relevant public health authorities, via your product’s software application (app), in accordance with local, state, and federal requirements, using appropriate LOINC and SNOMED codes, as defined by the “Laboratory In Vitro Diagnostics (LIVD) Test Code Mapping for SARS-CoV-2 Tests” provided by the Centers for Disease Control and Prevention (CDC).

Your product is a rapid, lateral flow immunoassay that involves the pre-mixing an    d binding of fluorophore specific to SARS-CoV-2 with viral nucleocapsid protein present in a patient specimen. First, the Processing Fluid is added into the Dropper to release the fluorophore. After collecting a mid-turbinate nasal specimen, the Nasal Swab is locked into the Dropper to release the viral antigens from the specimen, which are then bound by the fluorophore. An aliquot of the sample containing the fluorophore-labelled antigen complexes is dispensed into the Analyzer Sample Port. The deposited liquid wicks into the test strip by capillary action. The sample flows across a membrane and traverses a series of discrete capture zones, consisting of immobilized complementary antibodies to SARS-CoV-2 viral nucleoprotein. Fluorescence signals at the two test zones are detected using a single-use optoelectronics reader system, housed within the Analyzer. The tests and controls are interpreted according to thresholds set within the microprocessor contained in the Analyzer. The computed result is communicated to the app and displayed on the user’s smartphone and if selected are also emailed to the user. The total time for the test is 20 min, 5 min for test set up and 15 min once the analyser is activated.

Your product requires the following internal control materials, or other authorized control materials (refer to Condition L), that are processed along with the specimens. All internal controls listed below must generate expected results in order for a test result to be considered valid…    

III. Waiver of Certain Requirements

[FDA is] waiving the following requirements for your product for the duration of this EUA:

Current good manufacturing practice requirements, including the quality system requirements under 21 CFR Part 820 with respect to the design, manufacture, packaging, labeling, storage, and distribution of your product, but excluding Subpart H (Acceptance Activities, 21 CFR 820.80 and 21 CFR 820.86), Subpart I (Nonconforming Product, 21 CFR 820.90), and Subpart O (Statistical Techniques, 21 CFR 820.250)

(IV)(N). You must have lot release procedures and the lot release procedures, including the study design and statistical power, must ensure that the tests released for distribution have the clinical and analytical performance claimed in the authorized labeling.

(P) You must evaluate the analytical limit of detection and assess traceability7 of your product with any FDA-recommended reference material(s). After submission to and concurrence with the data by FDA, you will update your labeling to reflect the additional testing. Such labeling updates will be made in consultation with, and require concurrence of, DMD/OHT7- OIR/OPEQ/CDRH...
Fairly reassuring, though a number of technical questions remain at this point.

This company started following me on Twitter. Will have to probe further. Click the image above for the link.

Monday, December 14, 2020

Vax populi?

Let's hope these prove effective and safe in the field, worldwide. I'll be getting my vax as soon as it's available. We probably won't know about immunological efficacy until mid-2021 at best, given the massive scale of the logistics.

Until sufficient vax data accrue, the only "easy" and practical ongoing public countermeasures will be those of masks, social distance observance, and thorough hand-washing.
And rational mutual good will and patience, in a fractious time of increasing lack of them here in the U.S.
…The strength of a democratic society rests on its citizens’ ability to express their views and debate their merits. In the face of scientific uncertainty, economic pain, and conflicting values, it’s understandable that we disagree. But it’s also true that we know a lot about how the virus works, and that some views are beyond reasonable debate. Their persistence reflects a triumph of tribalism and the cowardice of those elected officials who have misused their influence, failing to protect the people they serve…

As a physician, I recognize that I’m also part of a tribe—one that celebrates science, authority, expertise. It’s easy for me to empathize with the suffering I see—hospitals full, patients dying, health-care workers overwhelmed—and harder to grasp the suffering I don’t: job loss, social disintegration, rising crime. By belittling or dismissing such concerns, instead of engaging and explaining, we divide the country further and compound the challenges of bringing the pandemic to heel. The Biden Presidency is an opportunity to reset how we talk about the virus, not just at the federal level but also in statehouses, hospitals, and public-health departments across the country. Biden has said, repeatedly, that he hopes to unify Americans. Almost certainly, this will require listening and responding to the concerns of the millions of people who see and experience the pandemic from a skeptical perspective…

…rarely, if ever, have so many lives depended so directly on the project of persuasion, empathy, and understanding. Faced with the prospect of the deadliest winter in modern U.S. history, we must not give up on that project. We cannot stop talking to one another.
There were 2.9 million new US Covid-19 cases reported (JHU) across the first 14 days of December. About 1.9% of those people will die. We could easily suffer more than a total of 500,000 deaths before too long, given the current and likely trajectory.
The images of the first people to receive the covid-19 vaccine promise the end of this particular nightmare. But it’s likely that hundreds of thousands more will die in the United States before the pandemic is over. The return to life without social distancing and isolation, the end to our loneliness, could proceed with unnecessary slowness because the Trump Administration did not secure as many doses of the vaccine as it could have. We have come to expect this President to fail Americans, catastrophically, and we have become accustomed to understanding these failures through two traits of his Administration: cruelty and militant incompetence. But there is a third one, characteristic of many, if not all, autocracies: indifference…"Masha Gessen
What was on my mind a year ago here?
America Is Running Out of Nurses
Travelling nurses have been moving from one hot spot to another. What happens when the hot spots keep multiplying?
More from Dr. Khullar.
Click the book cover image.



Thursday, December 10, 2020

A 9/11 a day

We've now surpassed 3,000 daily US Covid-19 fatalities.

More than 1.8 million new US cases across the first nine days of December. Nealry 300,000 Americans have died thus far. Current US mortality rate estimate is 1.94%. Do the arithmetic.
Click the image.
How many Americans will die of covid-19 before the vaccine reaches scale?

Within days, the United States will probably begin administering vaccines aimed at preventing the spread of the novel coronavirus that emerged last year. It will ramp up slowly, with states determining who receives immunization in what order. The goal is that the country eventually have a large enough population of individuals immune to the virus that it can’t spread easily, a goal that will take months to achieve.

In the meantime, how many more Americans will die?

We are experiencing more deaths from covid-19, the disease caused by the virus, than at any prior point in the pandemic. Both because of a failure at the individual level to take necessary precautions against the virus’s spread and because of a tacit embrace of inaction at the federal and, in some cases, state level, the virus has spread largely out of control for the past three months…

JHU data, from my little Excel sheet. Below, NBC News.


Sunday, December 6, 2020

Parkinson's during a pandemic

Dopamine and Microglia, Where Art Thou?

What a year. Last December I was formally dx'd with Parkinson's Disease (PD). Looking back, it was evident back in 2017, at which time I'd misattributed my encroaching symptoms to my relentless stress over my late younger daughter's pancreatic cancer ordeal.

There are about 12-13 cardinal PD symptoms. I now exhibit seven of them—tremor (on my left side), muscle stiffness, lightheadedness / balance issues (I'm an elevated fall risk), increasingly cramped, illegible handwriting, reduced sense of taste and smell, episodic chronic constipation, and fatigue. PD severity is typically ordinal-ranked in five stages—1-5. I am pretty firmly now a "2."
The tremor stuff now manifests itself as a twitchy left hand while using my mouse, LOL, causing me recurring inadvertent irrelevant ad click-thru's. I'm screwing up my Google-Facebook surveillance / tracking profile.
It's difficult to tease out some of these gnawing effects from those causally associated with our acutely worsening Covid-19 pandemic (not to mention the concomitant Trump Groundhog Day shitshow). Lying low interminably has its adverse upshots.

While my guitar chops are going to Hell, at least I can now auto-stir my coffee. Put the spoon in the cup, grab it, and off it goes.

I just have to be grateful for my relative good fortune. Great marriage, wonderful new grandson and great-grandson, great extended familiy and more friends than I deserve, financially solvent, fully back on pace with my life-long-unlearner voluminous reading, trying to stay positive, and get my focus back...

1.4 million new US Covid cases across the first 7 days of the month.

About 25k of that cohort will be dead in a month or so. And so on.

A US average of 203k new daily cases thus far, more than 1.6 million across the first 8 days of the month.

Ugh. But...

What can one say?

Thursday, December 3, 2020

Elections have consequences

One month since the November 2020 general election. More than 4 million new US Covid-19 cases since then, more than 100,000 Americans now hospitalized with the virus. More than 270,000 aggregate US deaths since the bug got here.

Oh, and the outgoing President wants the new vaccines soon to come on line to be named after him, according to his press secretary. 

I'm not making that up. She said it during a White House presser.


On Wednesday, more than three thousand Americans died because of the coronavirus, the nation’s deadliest day yet during the pandemic. The same day, the President of the United States chose to release, on social media, a forty-six-minute videotaped address from the White House. He called it possibly “the most important speech I’ve ever made.” The pandemic’s grim toll was never mentioned. What was? The “tremendous vote fraud and irregularities” in last month’s election, the results of which the President still refuses to accept. The “statistically impossible” victory of Joe Biden, and the idea that the Democrats had so “rigged” the election that “they already knew” the outcome in advance. It was all “corrupt,” “shocking,” “constitutionally absolutely incorrect,” and “so illegal.”…Susan Glasser


Our acute care inpatient facilities are fast approaching capacity. Don't get in a wreck or have an AMI.
"Since the beginning of the pandemic, public-health experts have warned of one particular nightmare. It is possible, they said, for the number of coronavirus patients to exceed the capacity of hospitals in a state or city to take care of them. Faced with a surge of severely ill people, doctors and nurses will have to put beds in hallways, spend less time with patients, and become more strict about whom they admit into the hospital at all. The quality of care will fall; Americans who need hospital beds for any other reason—a heart attack, a broken leg—will struggle to find space. Many people will unnecessarily suffer and die..."
And, as if that weren't enough, NY Times' Peter Baker notes:
Moody and by accounts of his advisers sometimes depressed, the president barely shows up to work, ignoring the health and economic crises afflicting the nation and largely clearing his public schedule of meetings unrelated to his desperate bid to rewrite the election results. He has fixated on rewarding friends, purging the disloyal and punishing a growing list of perceived enemies that now includes Republican governors, his own attorney general and even Fox News.

The final days of the Trump presidency have taken on the stormy elements of a drama more common to history or literature than a modern White House. His rage and detached-from-reality refusal to concede defeat evoke images of a besieged overlord in some distant dictatorship defiantly clinging to power rather than going into exile or an erratic English monarch imposing his version of reality on his cowed court…