One internet wag noted that a lot of these sports-legends-in-their-own-minds critics claiming "she's not tough enough" also whine that wearing a Covid-19 mask a couple hours a day while out in public is a "tyrannical burden."
NOW REPORTING FROM BALTIMORE. An eclectic, iconoclastic, independent, private, non-commercial blog begun in 2010 in support of the federal Meaningful Use REC initiative, and Health IT and Heathcare improvement more broadly. Moving now toward important broader STEM and societal/ethics topics. Formerly known as "The REC Blog." Best viewed with Safari, FireFox, or Chrome. NOTES, the Adobe Flash plugin is no longer supported. Comments are moderated, thanks to trolls.
Search the KHIT Blog
Thursday, July 29, 2021
Olympian Simone Biles
Tuesday, July 27, 2021
Monday, July 26, 2021
Anthropocene limits to growth, an update
AbstractFull paper here (pdf). Well worth your time. In 1972 I was 26, and I was dimly aware of the original study—notably that it was controversial. New, more comprehensive data tend to support the unhappy findings.
In the 1972 bestseller Limits to Growth (LtG), the authors concluded that, if global society kept pursuing economic growth, it would experience a decline in food production, industrial output, and ultimately population, within this century. The LtG authors used a system dynamics model to study interactions between global variables, varying model assumptions to generate different scenarios. Previous empirical data comparisons since then by Turner showed closest alignment with a scenario that ended in collapse. This research constitutes a data update to LtG, by examining to what extent empirical data aligned with four LtG scenarios spanning a range of technological, resource, and societal assumptions. The research benefited from improved data availability since the previous updates and included a scenario and two variables that had not been part of previous comparisons. The two scenarios aligning most closely with observed data indicate a halt in welfare, food, and industrial production over the next decade or so, which puts into question the suitability of continuous economic growth as humanity’s goal in the twenty-first century. Both scenarios also indicate subsequent declines in these variables, but only one—where declines are caused by pollution—depicts a collapse. The scenario that aligned most closely in earlier comparisons was not amongst the two closest aligning scenarios in this research. The scenario with the smallest declines aligned least with empirical data; however, absolute differences were often not yet large. The four scenarios diverge significantly more after 2020, suggesting that the window to align with this last scenario is closing.
Maybe it’s a function of who I follow on Twitter, but I didn’t see much in the way of “ring in the new year” chipperness. Seeing Australia go up in flames might have something to do with that, but even those who seemed awfully domestically focused also seemed subdued. I also noticed comparatively few “Year in review” or “Best of 2019/the past ten years” but that could just as well be due to the gutting of news rooms. Nevertheless, I thought I might be so bold as to offer a theory.
It’s not hard to see plenty of reasons why all save a select few (which includes the deluded and End of Days fans) have reason to be downbeat. Climate change. Mass species dieoff. Poisoning of the planet, particularly with plastics (that overlaps with dieoff but also creates day to day health and diet worries). Student debt. Short job tenures combined with mainly McJobs on offer. Often unaffordable and crapified health care. Having kids who ought to be able to go to college but need to be talked out of it since the debt load would be punitive. Fear over one’s likely inability to retire with the real risk of not being able to work. And that’s before getting to personal tragedies, like suffering a foreclosure or bankruptcy, or death, disability or drug addiction in the family. Shocks like that are even harder to take when so many things seem precarious.
To add to that long list, there’s more anxiety. Bizarrely fearful parenting even though the overwhelming majority of kids are safer than their free-range parents were at a similar age….and the riskiest thing kids do today on a regular basis is ride in a car. Anger and frustration over seemingly more and more Kafka-eque bureaucracies wreaking havoc. Surprisingly widespread diet fesithism. Anger about Trump. I’m sure readers could add to these lists.
None of these are news, but what seems to deepen the general gloom is a lack of confidence that anything will get better, a sense both of sorely limited personal power and lack of trust in those nominally in charge to do the right thing. And that is mademore intense by concerns about pending collapse. When the very richest people in the world are acting like preppers, there’s reason to be worried.
I am personally upset at being part of the problem. I now live in a freestanding house, which means energy inefficient. I use a car to get about. Public transportation here is pretty much non-existent, and please don’t advise walking or biking. Both are physically impossible.
I also despair at my inability to do anything other than take pathetically trivial steps to reduce how much plastic I wind up using. Even with being a Yankee and using things until they are about to or do fall apart, I do wind up buying some things. Even socks are in plastic! And forget about buying food in the US. Eggs? Yogurt? Berries? You’d be surprised at how few egg vendors use cardboard cartons. It’s even gotten hard to to buy loose lettuce down here (although oddly loose kale is a different story). Admittedly not everything is this way….but way too much is.
So why are we so stuck on a bad trajectory? Simple explanations are always simplistic, but I hazard that humans have seldom been good at working out how to manage competing levels of responsibility, and the tensions and contradictions get greater as societies become more complex…
Thursday, July 22, 2021
The Fox in the Covid19 Hen House
Get vaccinated. "Freedom" is not spelled "FreeDumb."
“Experts list many reasons for the vaccine slump, but one big reason stands out: vaccine resistance among conservative, evangelical, and rural Americans. Pro-Trump America has decided that vaccine refusal is a statement of identity and a test of loyalty.”—David Frum, The Atlantic
“[I]f there’s one thing we’ve all learned by now in the pandemic, it’s that public health and politics are one and the same: there is no way to separate them. Biden came into office pledging to follow the science, to vaccinate the country and lead the recovery. But he could not vaccinate the country against Fox News.” —Susan B. Glasser, The New Yorker
Sarah Huckabee Sanders' pitch on Fox: "If I'm elected governor here in Arkansas, we will not have mask mandates, we will not have mandates on the vaccine, we will not shut down churches and schools & other large gatherings because we believe in personal freedom & responsibility."
Drug testing is conventionally viewed as an effective and necessary means of both deterring illicit drug use and identifying those in need of “treatment” for their “addictions.” Widely employed in competitive amateur and professional sports, mandatory drug testing programs are now policy in 80% of major U.S. corporations according to an American Management Association report... Recent federal legislative proposals have sought to extend mandatory testing to all branches of the federal government and to all direct or indirect recipients of federal funds (e.g., welfare and public housing clients, students receiving government backed school loans, businesses with federal contracts, etc.)…
Sunday, July 18, 2021
The Anthropocene and the FSMLs: "Science" editorial
Sitting at the interface of human societies and the natural environment are sentinels tracking environmental change. Across the globe, field stations and marine laboratories (FSMLs) amass crucial information about climate, biodiversity, environmental health, and emerging diseases, anchoring multidecadal data sets needed to solve environmental challenges of the Anthropocene. These observatories are now in danger of being shut down—part of the collateral damage of the COVID-19 pandemic…Science Magazine
As Earth's population swells to 8 billion, understanding and predicting human impacts on the planet become ever more urgent. Both long-term and real-time data are needed to quantify the repercussions of deforestation, agricultural intensification, desertification, climate change, ocean acidification, and other stresses if we are to mitigate their effects, plan adaptive responses, and develop national and international policies. Nature's struggles are humanity's struggles: As biodiversity is lost and ecosystems erode, so will the quality of our air, waters, and soils. This degradation will also affect the essential ecosystem services that nature consistently provides. Crop pollination services alone are estimated as a $500 billion annual benefit for society. And emerging pathogens will continue to be a threat across all borders. Environmental data to guide sound, science-based solutions, and broader public understanding and engagement, are necessary to overcome these mounting environmental challenges.
FSMLs are essential for educating and training the next generation of scientists. Immersive in situ experiences are foundational to those seeking careers in biology and ecology, geology and soil science, oceanography, hydrology and limnology, meteorology, conservation, and resource management. Evidence shows that field courses close demographic gaps in science participation and persistence and improve diversity across disciplines. Virtual materials and live-stream research-based field experiences simply cannot supplant place-based learning, curiosity-driven exploration, the life-changing value of discovery, and the realization that Earth is still a little-known planet. Furthermore, FSMLs play a broader role in education. Field course alumni become educators and school administrators, or pursue careers in medicine, law, social services, and business, among other professions. Scientists and nonscientists alike take away a deeper understanding and appreciation for nature and a propensity to embrace an ethic of planetary stewardship…
The pandemic has cut revenue streams to FSMLs for a second year. At a time when environmental issues demand even greater attention, the world cannot risk undermining their contributions to scientific literacy, environmental research, and student training—all of which are essential to protect Earth's bountiful natural heritage and life-sustaining ecosystems. Universities, governments, and other organizations must find ways to save these global sentinels—all life depends on them...
Monday, July 12, 2021
Baked Alaska:
...We are imposing a rate of change on the planet that has almost never happened before in geologic history, while largely preventing life on Earth from adjusting to that change.Taking in the whole sweep of Earth’s history, now we see how unnatural, nightmarish, and profound our current experiment on the planet really is. A small population of our particular species of primate has, in only a few decades, unlocked a massive reservoir of old carbon slumbering in the Earth, gathering since the dawn of life, and set off on a global immolation of Earth’s history to power the modern world. As a result, up to half of the tropical coral reefs on Earth have died, 10 trillion tons of ice have melted, the ocean has grown 30 percent more acidic, and global temperatures have spiked. If we keep going down this path for a geologic nanosecond longer, who knows what will happen? The next few fleeting moments are ours, but they will echo for hundreds of thousands, even millions, of years. This is one of the most important times to be alive in the history of life.
NOTE: I routinely keyword/phrase search the books I study and cite here for core terms. Fundamental to science is "evidence." I have by now gotten a cumulative couple thousand hits for the word across these volumes. But, not yet a single definition. We all assume we mean the same thing, but then come to loggerheads over what it denotes during contentious issue debates (in science and beyond). I have spent a lot of time studying legal reasoning. I don't take much for granted. Pedantic, yeah, I know.ANTI-VAXX UPDATE
"Free speech" and all that.
Global warming
Pandemic(s)
Economic disruption
Academic turmoil
Social/racial justice upheaval
Threats to democracy
Pollution
Firearms violence
Migration crises
Cybercrime
Ahem... Seriously, no shortage of major issues in need of sustained serious, rational, deliberative attention.Britney Spears' conservatorship dispute
Sunday, July 11, 2021
Chasing the SARS-Cov-2 variants
AbstractInteresting paper (open source Creative Commons). Read all of it. We will continue to shoot at a moving vaxx target.
The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is th.e molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical interventions. With the emergence of new strains of SARS-CoV-2 with altered transmissibility and immune evasion potential, a critical question is this: how easily can the virus escape neutralizing antibodies (nAbs) targeting the spike RBD? To answer this question, we combined an analysis of the RBD structure-function with an evolutionary modeling framework. Our structure-function analysis revealed that epitopes for RBD-targeting nAbs overlap one another substantially and can be evaded by escape mutants with ACE2 affinities comparable to the wild type, that are observed in sequence surveillance data and infect cells in vitro. This suggests that the fitness cost of nAb-evading mutations is low. We then used evolutionary modeling to predict the frequency of immune escape before and after the widespread presence of nAbs due to vaccines, passive immunization or natural immunity. Our modeling suggests that SARS-CoV-2 mutants with one or two mildly deleterious mutations are expected to exist in high numbers due to neutral genetic variation, and consequently resistance to vaccines or other prophylactics that rely on one or two antibodies for protection can develop quickly -and repeatedly- under positive selection. Predicted resistance timelines are comparable to those of the decay kinetics of nAbs raised against vaccinal or natural antigens, raising a second potential mechanism for loss of immunity in the population. Strategies for viral elimination should therefore be diversified across molecular targets and therapeutic modalities.
Discussion
...The evolvability of SARS-CoV-2 in response to selection pressure will determine the ultimate tractability of our efforts at disease control. Our work suggests that the capacity of SARS-CoV-2 to evade the immune system may be greater than originally anticipated and raises the specter of a process of ongoing and continuous evolution in response to antibody-based prophylaxis, occurring on a timescale that may not be convenient or tractable for the design of novel biomedical interventions. Thus, our findings speak to the need for both public health and biomedical intervention strategies targeting SARS-CoV-2 to be designed to account for the risk of rapid evolutionary response to biomedical interventions.
Thursday, July 8, 2021
#CriticalRaceWeary
According to their poignant Lead Counsel John Coale, "Big Tech" are now explicitly "government actors," and there's nothing SCOTUS hates more than "prior restraint"—he cites, in unfortunate analogy, The Pentagon Papers case (uh, well, the DOJ plaintiffs lost that one, recall). Tilt.
Also noteworthy in that regard: irrespective of the "restraints" eventually imposed on Mr. Trump, none were "prior." They were all post-hoc reactive to his innumerable ToS violations, many of which went to implicit and explicit incitements to violence. Moreover, he was head of the government at the time of his sanctioning. How come he didn't simply order the social media "government actors" to abide his public "communications?"
Monday, July 5, 2021
Maryland "VaxCash." Hey, whatever works.
Maryland (my state of residence since April 2019) is not the only state doing this. We're now doling out a random $40k per day to documentably vaxxed residents. I have no idea what the cost/benefit estimates are for this effort. But, I seriously doubt our Republican governor would have approved a financially profligate feel-good initiative.
Within weeks of the onset of the virus, a barrage of confusing, misleading, and inaccurate information spread faster than the virus itself. Misinformation was coming from all corners: politicians, newscasts, social media, dark web conspiracy theorists, and even the presidential briefing room. Never has it been so imperative that individuals have the skills to understand scientific inquiry and know how to evaluate what they read and hear. Nor has it ever been more critical that policy makers listen to scientists and make use of scientific data to guide decisions to protect their communities, states, and countries. The first vaccine received emergency approval in mid-December 2020, others have followed, and the rate of vaccinations grows. Yet worries persist about whether enough citizens will choose to be vaccinated, a deeply concerning problem when such decisions affect others’ lives, not just one’s own.See also my "Science Communication" posts.
Sinatra, Gale; Hofer, Barbara. Science Denial (p. x). Oxford University Press. Kindle Edition.
Six months after the attack on the Capitol triggered by that lie, commentators, political scientists, and families around the dinner table still struggle to come to grips with perverse reality. It is natural to want to understand how we got here. The fate of our democracy turns on not just what our electorate believes but why they believe it. Why are a third of us such gullible rubes?Yeah. "Read a book," indeed. I try to do 2-3 a week.
We are as a society—and by “we” I mean virtually all of us on the planet —brought up to believe howling absurdities, ridiculous impossibilities, and insupportable malarkey from our very first moments on Earth. We have massive lie-delivery systems that are the core institutions of our society. And we have created cultural barriers to even questioning those fabrications which are most deserving of skeptical scrutiny. For example, we regularly label as sacred those ideas that are least able to stand up to scrutiny. (Heck, we have folks in our society who can’t even handle the idea that the history we teach our kids might actually be based on what happened, you know, back in the past.)
Our parents lie to us. Our churches, synagogues, and mosques like to us. Our schools lie to us. Hollywood lies to us. Madison Avenue lies to us. The media lies to us. Our leaders lie to us. Our friends lie to us. (They do. Going to the gym couldn’t hurt.)
What is more the lies they offer are not always big lies (e.g. Buying a particular brand of beer will not make you more attractive) while some are just gross oversimplifications (e.g. The Founding Fathers did a lot of good... but they were not the figures carved out of marble we were sold for years). Some have a seed of truth within them but are gross distortions (e.g. Columbus did not discover America). And some of the time we invite the lies because they open the door to enjoyment (e.g. Keto? All the bacon I can eat? I’m in).
But one of the key reasons we buy into so many small lies is that we have been force fed so many big ones. I mean really big ones. I mean ones that make the current Big Lie look like one of those low-calorie snacks that is actually a high-calorie treat shrunk to a smaller size and repackaged.
The original big lies are so big that if you are like most people some of them are ingrained in your identity, they are who you are. They come from religions and heritage. They are cooked into the primal soup of our minds. Many of them have been around for longer than many of the “facts” we have and as such are so covered in the dust of history and tradition that they appear to be as substantial as what is true. Indeed, some have a timeworn patina that makes them seem almost more important than that which is verifiable or even knowable.
Social science research gives a variety of reasons for why we are inclined to believe “alternative facts.” (Studies show a person is “quick to share a political article on social media if it supports their beliefs, but is more likely to fact check a story if it doesn’t.” We tend to vote for what we want to be true or what our friends believe. According to Peter Ditto, a social psychologist at the University of California, “our wishes, hopes, fears and motivations often tip the scales to make us more likely to accept something as true if it supports what we want to believe.” That said, another reason is often cited for our willingness to buy into the bullshit we are being fed. According to a 2019 University of Regina study, “People who believe false headlines tended to be the people (who) didn’t think carefully, regardless of whether those headlines aligned with their ideology.” So, one way or another, we fall for fake news because it’s easier for us, socially or intellectually.
Many of these lies were created out of necessity. Life is finite. (OK, I’m sorry. It is. Take a deep breath if you need to and then continue reading.) If we don’t come up with a good story about what happens after it ends or why we are here we will all go mad. So we make up preposterous stories about magic people in the sky and then immediately say that we cannot question those stories, that “faith” in them is more important than knowledge of what is real. Why? Because they will not stand up to scrutiny.
When challenged, the defenders of these original big lies say the truth is unknowable. Good try. Hard to argue with that. We don’t know there is not an omniscient rule-maker beyond the clouds or a heaven filled with virgins to give pleasure to the faithful so how can you question it? But of course, selling what is unknowable as a truth is one of the most important categories of lies we encounter in life. Indeed, it is the foundation of much of (speculation-based and often hooey-ridden) human philosophy. And it works.
There are other big lies, of course. Some are related to the religious lies—like the divine right of kings or the lie that the clergy somehow are more in touch with truth than, say, scientists who actually devote their lives to studying the truth. Some come from political leaders. For example, the lie that to die in war is glorious is one that has done irreparable damage for eons. It has been disproven for thousands of years and yet remains so essential to getting young men and women to give up their lives to serve the ambitions of the rich and powerful that it endures. You know many of the other lies that have lived for centuries—about the superiority of races or genders or nationalities, about patriotism, about comforting ideas like that everything is for the best or things work out in the end. It’s not. They don’t. Read a book.
Sunday, July 4, 2021
An Independence Day reflection
CARLOS AND RANGER ARE NOT JULY 4TH FANSIn Congress, July 4, 1776
The unanimous Declaration of the thirteen united States of America, When in the Course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Nature's God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.
We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.--That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, --That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness. Prudence, indeed, will dictate that Governments long established should not be changed for light and transient causes; and accordingly all experience hath shewn, that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed. But when a long train of abuses and usurpations, pursuing invariably the same Object evinces a design to reduce them under absolute Despotism, it is their right, it is their duty, to throw off such Government, and to provide new Guards for their future security.--Such has been the patient sufferance of these Colonies; and such is now the necessity which constrains them to alter their former Systems of Government. The history of the present King of Great Britain is a history of repeated injuries and usurpations, all having in direct object the establishment of an absolute Tyranny over these States. To prove this, let Facts be submitted to a candid world.
He has refused his Assent to Laws, the most wholesome and necessary for the public good.
He has forbidden his Governors to pass Laws of immediate and pressing importance, unless suspended in their operation till his Assent should be obtained; and when so suspended, he has utterly neglected to attend to them.
He has refused to pass other Laws for the accommodation of large districts of people, unless those people would relinquish the right of Representation in the Legislature, a right inestimable to them and formidable to tyrants only.
He has called together legislative bodies at places unusual, uncomfortable, and distant from the depository of their public Records, for the sole purpose of fatiguing them into compliance with his measures.
He has dissolved Representative Houses repeatedly, for opposing with manly firmness his invasions on the rights of the people.
He has refused for a long time, after such dissolutions, to cause others to be elected; whereby the Legislative powers, incapable of Annihilation, have returned to the People at large for their exercise; the State remaining in the mean time exposed to all the dangers of invasion from without, and convulsions within.
He has endeavoured to prevent the population of these States; for that purpose obstructing the Laws for Naturalization of Foreigners; refusing to pass others to encourage their migrations hither, and raising the conditions of new Appropriations of Lands.
He has obstructed the Administration of Justice, by refusing his Assent to Laws for establishing Judiciary powers.
He has made Judges dependent on his Will alone, for the tenure of their offices, and the amount and payment of their salaries.
He has erected a multitude of New Offices, and sent hither swarms of Officers to harrass our people, and eat out their substance.
He has kept among us, in times of peace, Standing Armies without the Consent of our legislatures.
He has affected to render the Military independent of and superior to the Civil power.
He has combined with others to subject us to a jurisdiction foreign to our constitution, and unacknowledged by our laws; giving his Assent to their Acts of pretended Legislation:
For Quartering large bodies of armed troops among us:
For protecting them, by a mock Trial, from punishment for any Murders which they should commit on the Inhabitants of these States:
For cutting off our Trade with all parts of the world:
For imposing Taxes on us without our Consent:
For depriving us in many cases, of the benefits of Trial by Jury:
For transporting us beyond Seas to be tried for pretended offences
For abolishing the free System of English Laws in a neighbouring Province, establishing therein an Arbitrary government, and enlarging its Boundaries so as to render it at once an example and fit instrument for introducing the same absolute rule into these Colonies:
For taking away our Charters, abolishing our most valuable Laws, and altering fundamentally the Forms of our Governments:
For suspending our own Legislatures, and declaring themselves invested with power to legislate for us in all cases whatsoever.
He has abdicated Government here, by declaring us out of his Protection and waging War against us.
He has plundered our seas, ravaged our Coasts, burnt our towns, and destroyed the lives of our people.
He is at this time transporting large Armies of foreign Mercenaries to compleat the works of death, desolation and tyranny, already begun with circumstances of Cruelty & perfidy scarcely paralleled in the most barbarous ages, and totally unworthy the Head of a civilized nation.
He has constrained our fellow Citizens taken Captive on the high Seas to bear Arms against their Country, to become the executioners of their friends and Brethren, or to fall themselves by their Hands.
He has excited domestic insurrections amongst us, and has endeavoured to bring on the inhabitants of our frontiers, the merciless Indian Savages, whose known rule of warfare, is an undistinguished destruction of all ages, sexes and conditions.
In every stage of these Oppressions We have Petitioned for Redress in the most humble terms: Our repeated Petitions have been answered only by repeated injury. A Prince whose character is thus marked by every act which may define a Tyrant, is unfit to be the ruler of a free people.
Nor have We been wanting in attentions to our Brittish brethren. We have warned them from time to time of attempts by their legislature to extend an unwarrantable jurisdiction over us. We have reminded them of the circumstances of our emigration and settlement here. We have appealed to their native justice and magnanimity, and we have conjured them by the ties of our common kindred to disavow these usurpations, which, would inevitably interrupt our connections and correspondence. They too have been deaf to the voice of justice and of consanguinity. We must, therefore, acquiesce in the necessity, which denounces our Separation, and hold them, as we hold the rest of mankind, Enemies in War, in Peace Friends.
We, therefore, the Representatives of the united States of America, in General Congress, Assembled, appealing to the Supreme Judge of the world for the rectitude of our intentions, do, in the Name, and by Authority of the good People of these Colonies, solemnly publish and declare, That these United Colonies are, and of Right ought to be Free and Independent States; that they are Absolved from all Allegiance to the British Crown, and that all political connection between them and the State of Great Britain, is and ought to be totally dissolved; and that as Free and Independent States, they have full Power to levy War, conclude Peace, contract Alliances, establish Commerce, and to do all other Acts and Things which Independent States may of right do. And for the support of this Declaration, with a firm reliance on the protection of divine Providence, we mutually pledge to each other our Lives, our Fortunes and our sacred Honor.